Database Authors
Renato H. Orsi, Department of Food Science - Cornell University; Teresa M. Bergholz, Department of Food Science - Cornell University; Martin Wiedmann, Department of Food Science - Cornell University; Kathryn J. Boor, Department of Food Science - Cornell University
Summary Listeria monocytogenes 10403S is a bacterial foodborne pathogen that causes a disease known as listeriosis in human and other animals. The genus Listeria is named after the British scientist Joseph Lister, who promoted the idea of sterile surgery. This serotype 1/2a strain is used by the majority of investigators in the U.S. studying the pathogenesis of Listeria monocytogenes. 10403S is a streptomycin resistant isolate of strain 10403, which was first reported by [Edman68] as an isolate from a human skin lesion obtained from Montana State University and is further described in [Bishop87].

This Pathway/Genome Database (PGDB) was created by a team from Cornell University [Orsi15] from the annotated genome using the PathoLogic component of the Pathway Tools software [Karp11, Karp19] and the MetaCyc reference database [Caspi20]. The PGDB, which integrates the biochemical reaction network and metabolic pathways of the organism with its genome, was improved by limited manual curation.

Genome
RepliconTotal GenesProtein GenesRNA GenesPseudogenesSize (bp)NCBI Link
Chromosome2,9792,82815102,903,106
Ortholog data available?Yes
Database Contents
Genes2,979
Pathways260
Enzymatic Reactions1,234
Transport Reactions123
Polypeptides2,828
Protein Complexes26
Enzymes734
Transporters392
Compounds934
Transcription Units1,734
tRNAs85
Transcriptional Regulation181
Protein Features3,873
GO Terms360
Database Version29.0
Taxonomic Lineage cellular organisms
Bacteria <bacteria>
Terrabacteria group
Bacillota
Bacilli
Bacillales
Listeriaceae
Listeria
Listeria monocytogenes
Listeria monocytogenes 10403S
Genetic Code Number 11 -- Bacterial, Archaeal and Plant Plastid (same as Standard, except for alternate initiation codons)
GOLD0001557
NCBI-Taxonomy393133
Relationship to Oxygenfacultative
Trophic Levelheterotroph
Temperature Rangemesophile
Biotic Relationshipparasite
Pathogenicityhuman

References

Bishop87: Bishop DK, Hinrichs DJ (1987). "Adoptive transfer of immunity to Listeria monocytogenes. The influence of in vitro stimulation on lymphocyte subset requirements." J Immunol 139(6);2005-9. PMID: 3114382

Caspi20: Caspi R, Billington R, Keseler IM, Kothari A, Krummenacker M, Midford PE, Ong WK, Paley S, Subhraveti P, Karp PD (2020). "The MetaCyc database of metabolic pathways and enzymes - a 2019 update." Nucleic Acids Res 48(D1);D445-D453. PMID: 31586394

Edman68: Edman DC, Pollock MB, Hall ER (1968). "Listeria monocytogenes L forms. I. Induction maintenance, and biological characteristics." J Bacteriol 96(2);352-7. PMID: 4970647

Karp11: Karp PD, Latendresse M, Caspi R (2011). "The pathway tools pathway prediction algorithm." Stand Genomic Sci 5(3);424-9. PMID: 22675592

Karp19: Karp PD, Midford PE, Billington R, Kothari A, Krummenacker M, Latendresse M, Ong WK, Subhraveti P, Caspi R, Fulcher C, Keseler IM, Paley SM (2019). "Pathway Tools version 23.0 update: software for pathway/genome informatics and systems biology." Brief Bioinform. PMID: 31813964

Orsi15: Orsi RH, Bergholz TM, Wiedmann M, Boor KJ (2015). "The Listeria monocytogenes strain 10403S BioCyc database." Database (Oxford) 2015. PMID: 25819074

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